Prof. Youssef Idaghdour

Dr. Yossef’s research interest lies in Genetic and genomics, and medical genomics of cardio-metabolic

phenotypes. The overarching goal of his research is to understand how genomes and environment

interact at various levels of biological variation moving from the architecture of the genome itself to

protein function and transitioning through the complex modes of epigenetic and gene expression

regulation. He is particularly interested in studying the role genetic and environmental factors play in

shaping health-related phenotypes and how interactions between these effects trigger complex

diseases and modulate their outcome. To achieve these goals, we generate high-dimensional genomic

datasets from single-cells, tissues, and cells, and use bioinformatics and statistical genetic approaches

to analyze the data.

Health Advice: 

“sleep well and surround yourself with positive people”.

Publications

Favé MJ, …., Idaghdour Y, Awadalla P (2018) Gene-by-environment interactions in urban populations modulate risk phenotypes. Nature Communications 6;9(1):827.

 Idaghdour Y, Hodgkinson A (2017) Integrated genomic analysis of mitochondrial RNA processing in human cancers. Genome Medicine 20179:36.

Hodgkinson A*, Idaghdour Y*, et al. (2014) High-resolution genomic analysis of human mitochondrial RNA sequence variation. Science 344(6182):413-5.

The 1000 Genomes Project Consortium (2010) A map of human genome variation from population scale sequencing. Nature 467: 1061-1073.

Idaghdour Y et al. (2010) Geographical Genomics of Human LeGeographical Genomics of Human Leukocyte Gene Expression Variation in Southern Morocco. Nature Genetics 42(1): 62-67.