Dr. Yossef’s research interest lies in Genetic and genomics, and medical genomics of cardio-metabolic
phenotypes. The overarching goal of his research is to understand how genomes and environment
interact at various levels of biological variation moving from the architecture of the genome itself to
protein function and transitioning through the complex modes of epigenetic and gene expression
regulation. He is particularly interested in studying the role genetic and environmental factors play in
shaping health-related phenotypes and how interactions between these effects trigger complex
diseases and modulate their outcome. To achieve these goals, we generate high-dimensional genomic
datasets from single-cells, tissues, and cells, and use bioinformatics and statistical genetic approaches
to analyze the data.
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